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Press release from Business Wire

Law Offices of Howard G. Smith Announces Investigation of ISIS Pharmaceuticals, Inc.

Thursday, January 03, 2013

Law Offices of Howard G. Smith Announces Investigation of ISIS Pharmaceuticals, Inc.16:30 EST Thursday, January 03, 2013 Law Offices of Howard G. Smith announces that it is investigating potential claims against ISIS Pharmaceuticals, Inc. (“ISIS” or the “Company”) (NASDAQ:ISIS) concerning possible violations of federal securities laws. ISIS engages in the discovery and development of drugs utilizing antisense technology to primarily treat cardiovascular, metabolic, and severe and rare diseases, including cancer. The investigation is related to allegations that the Company issued materially false and misleading statements regarding the safety and efficacy of Kynamro (mipomersen sodium) -- the Company's flagship product for the treatment of patients with Homozygous Familial Hypercholesterolaemia. BENSALEM, Pa. (Business Wire) -- On October 16, 2012 the U.S. Food and Drug Administration published a clinical briefing document raising concerns regarding the safety and efficacy of Kynamro, noting among other things, abnormal growths or neoplasms developed in 3.1% of patients treated with Kynamro, as compared to only 0.9% of patients who took a placebo; that the data submitted by the Company was limited by a small sample size and a short treatment time, and that during the clinical testing two patients treated with Kynamro died of heart attacks and another patient died of acute liver failure. Following this news, ISIS shares declined nearly 22%, to close at $10.27 on October 16, 2012. If you purchased ISIS securities between March 29, 2012 and October 15, 2012, if you have information or would like to learn more about these claims, or if you wish to discuss these matters or have any questions concerning this announcement or your rights or interests with respect to these matters, please contact Howard G. Smith, Esquire, of Law Offices of Howard G. Smith, 3070 Bristol Pike, Suite 112, Bensalem, Pennsylvania 19020 by telephone at (215) 638-4847, Toll Free at (888) 638-4847, or by email to howardsmith@howardsmithlaw.com, or visit our website at http://www.howardsmithlaw.com. Law Offices of Howard G. SmithHoward G. Smith, Esquire(215) 638-4847(888) 638-4847howardsmith@howardsmithlaw.comwww.howardsmithlaw.com