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CHICAGO — Older people who have had a stroke or mini-stroke benefit from cholesterol-lowering statin drugs just as much as younger people do, U.S. researchers said on Wednesday.
"Even though the majority of strokes and heart attacks occur in people who are 65 and older, studies have found that cholesterol-lowering drugs are not prescribed as often for older people as they are for younger people," Dr. Seemant Chaturvedi of Wayne State University in Detroit, Michigan, said in a statement.
"These results show that using these drugs is just as beneficial for people who are over 65 as they are for younger people."
In April, British researchers reported in the New England Journal of Medicine that treating high blood pressure in people 80 and older cut their risk of fatal strokes and other heart problems.
Statins reduce the risk of heart attack or stroke by lowering levels of fatty substances such as low-density lipoprotein – "bad" cholesterol – and triglycerides. They also raise levels of high-density lipoprotein – "good" cholesterol.
Thee medications include atorvastatin, made by Pfizer Inc. under the brand name Lipitor; pravastatin or Pravachol, made by Bristol-Myers Squibb; fluvastatin, made by Novartis AG under the brand name Lescol, and several others.
Dr. Seemant and colleagues studied 4,731 people 18 and older who had a recent stroke or a mini-stroke as part of a study sponsored by Pfizer.
About half were 65 or older, with an average age of 72. The other half were younger than 65 and had an average age of 54. In each age group, about half were taking Lipitor and the other half were on a placebo.
The statin worked equally well in both age groups, the researchers reported in the journal Neurology. It lowered LDL cholesterol by about 61 points in the group of older patients and by about 59 points in the younger age group.
Stroke is the No. 3 killer in the United States behind heart disease and cancer. The U.S. Centers for Disease Control and Prevention estimate that 780,000 Americans will suffer strokes this year. The strokes will kill 150,000 people and permanently disable 15 per cent to 30 per cent of survivors.
