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Andrew Robinson threw for a career-high 423 yards and four touchdowns to help Syracuse stun No. 18 Louisville 38-35.

Taj Smith caught four passes for 173 yards and two touchdowns for the Orange (1-3, 1-0 Big East) as Syracuse ended Louisville's 20-game home winning streak by dominating the listless Cardinals (2-2, 0-1).

The victory was Syracuse's first road conference win and first victory over a ranked team since beating Boston College at the end of the 2004 season.

Brian Brohm completed 45 of 65 passes for a career-high 555 yards and four scores for Louisville, but the Cardinals' defence allowed Syracuse — which entered the game ranked near the bottom nationally in every offensive category — to pile up 465 yards and make big play after big play.

No. 3 Florida 30, Mississippi 24

At Oxford, Miss., Tim Tebow passed for two touchdowns, ran for two more and set a school record for quarterbacks with 166 yards rushing.

The Gators (4-0) got off to a slow start and allowed the Rebels (1-3) back into the game at the start of the fourth quarter.

But Tebow came up with a handful of clock-killing runs after he engineered two second-half touchdown drives, scoring on a six-yard run and throwing a 37-yard touchdown pass to Louis Murphy.

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No. 5 West Virginia 48, East Carolina 7

At Morgantown, W.Va., Pat White threw for two touchdowns and ran for two more.

Steve Slaton rushed for 110 yards and a score to match a school record for career touchdowns, and the Mountaineers (4-0) rolled up 599 total yards against the Pirates (1-3), who suffered their most lopsided loss under third-year coach Skip Holtz.

The Mountaineers didn't allow a score until the final two minutes, limiting the Pirates to nine first downs and 160 total yards.

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No. 15 Clemson 42, N.C. State 20

At Raleigh, N.C., C.J. Spiller and James Davis each caught a touchdown pass and rushed for another.

Davis rushed for a season-high 166 yards with a three-yard touchdown catch and a one-yard scoring run, while Spiller — a week after Furman held him to minus-1 yard — finished with 114 yards with an 11-yard TD catch and a 44-yard scoring run.

The Tigers (4-0, 2-0 Atlantic Coast Conference) dominated N.C. State (1-3, 0-2) from the opening kickoff, scoring on four of their first five possessions and at one point outgaining the Wolfpack 220-1.

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No. 23 South Florida 37, North Carolina 10

At Tampa, Fla., South Florida validated its first Top 25 ranking and the Bulls set themselves up for next week's much-anticipated Big East showdown against No. 5 West Virginia.

Matt Grothe led long touchdown drives on USF's first two possessions, while the Bulls' swarming defence forced four turnovers and kept the young, rebuilding Tar Heels out of the end zone until just over a minute remained.

Grothe completed 17 of 30 passes for 230 yards and one touchdown before being replaced by backup Grant Gregory in the fourth quarter. The Bulls (3-0) also rushed for 194 yards and outgained North Carolina (1-3) 428-164 overall.

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No. 24 Nebraska 41, Ball St. 40

At Lincoln, Neb., Sam Keller's fourth touchdown pass finally put Nebraska in the lead with 3:13 left in the game, and the 24th-ranked Cornhuskers survived an upset bid.

The Cardinals moved in position to win the game in the final seconds, but Jake Hogue's 55-yard field goal attempt was wide left, allowing Cornhuskers fans everywhere to breathe a sigh of relief.

Keller passed for a school-record 438 yards, and Nebraska needed every one of them against the 23-point underdog Cardinals.