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Calgary quarterback Kevin Glenn is reportedly set to start for the Stampeders after missing two games with a back injury.BEN NELMS/Reuters

Montreal Alouettes (4-7)

at Hamilton Tiger-Cats (5-6)

Saturday, 4 p.m. (EDT)

The third instalment of Touchdown Atlantic in Moncton, features the first match-up of the year between the Tabbies and Als – the latest that has happened in a season in 52 years, according to the CFL.

Hamilton is rounding into form and should have beaten the league-leading Calgary Stampeders last week.

Its CFL-best offence, led by quarterback Henry Burris, will put the Montreal defence to the test.

Stand-in Alouettes quarterback Tanner Marsh is out with a thumb injury, meaning Josh Neiswander gets the call as the injured Anthony Calvillo's replacement.

Hamilton's secondary is decimated by injuries, but Montreal's offence is anemic to the point where it might not matter.

The pick: Hamilton

Toronto Argonauts (7-4)

at Calgary Stampeders (9-2)

Saturday, 7:30 p.m. (EDT)

Toronto is the CFL's best road team, which would surely be more significant if it was visiting any place other than Calgary.

The Stamps beat the Argos 35-15 in their first meeting in Week 9, are perfect at home this year (5-0), and are riding a 10-game home win streak, the longest in the league in 15 years.

Calgary found a way to win against Hamilton last week, and has shot to the top of the CFL standings despite a revolving door at quarterback.

Kevin Glenn is reportedly set to start for the Stamps after missing two games with a back injury, the Argos will be led by backup Zach Collaros, who has concocted two consecutive road wins.

Toronto's improving defence could be a factor in this one, as it showed in last year's Grey Cup, it is adept at neutralizing star running back Jon Cornish.

The pick: Calgary

B.C. Lions (7-4)

at Saskatchewan Roughriders (8-3)

Sunday, 4:30 p.m. (EDT)The Lions have been a .500 team the past month, and now travel to the CFL's least-hospitable environment.

At least they're up against a Riders squad that has lost two in a row.

Plainly put, this is a match-up featuring a pair of scuffling, banged-up teams.

B.C. quarterback Travis Lulay hurt his shoulder in last week's win over Montreal, the untested Thomas Demarco is expected to be thrown into the fray for his first professional start.

On Saskatchewan's side of the ball, the loss of CFL leading rusher Kory Sheets to a knee sprain will force a rethink on offence.

The Lions have won just once on the road this season, and Saskatchewan has lost just once at home.

If the Lions are to win, their veteran defence will have to carry the day.

It's a tall order.

The pick: Saskatchewan

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