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Lewis McGugan, left, scored his second goal of the season to send Sheffield Wednesday through with a 1-0 League Cup win.Lee Smith/Reuters

Newcastle's troubled season lurched to another low when the Premier League strugglers were knocked out of the League Cup by second-tier Sheffield Wednesday, while Liverpool only avoided embarrassment against fourth-tier Carlisle United by winning on penalties on Wednesday.

Liverpool only led briefly in the first half at Anfield through Danny Ings's goal, with Derek Asamoah quickly levelling to force the game into extra time. In the shootout, Liverpool goalkeeper Adam Bogdan made three saves on his debut to ensure Carlisle was beaten 3-2 in the third round.

Newcastle's home humiliation to a second-string Wednesday side came as Steve McClaren remains winless this season in the Premier League after six games in charge. Lewis McGugan netted for only the second time this season, on his fourth appearance to send Wednesday through with a 1-0 win.

Arsenal eliminated Tottenham in a north London derby, with the 2-1 victory secured by Mathieu Flamini grabbing his first career double on his first appearance of the season. Defender Calum Chambers had scored an own goal to level the game before Flamini's sublime first-time volley sent Arsenal into the fourth round.

"I had a point to prove, I haven't played for a while," the 31-year-old Flamini said. "But I'm working hard."

After the game at White Hart Lane, some Arsenal fans ripped up Tottenham signs and briefly clashed with security personnel.

Unlike Newcastle, four other Premier League teams had no problem dispensing of lower-league teams.

Anthony Martial made it four goals in four games at the start of his Manchester United career by completing a 3-0 victory over Ipswich. Wayne Rooney also netted his first domestic goal of the season and 19-year-old midfielder Andreas Pereira scored his first United goal on his first start from a dipping free kick.

Ramires, Loic Remy, Kenedy and Pedro Rodriguez scored as Chelsea eased to a 4-1 victory over Walsall after the third-tier hosts briefly reduced the deficit to 2-1.

Southampton thrashed MK Dons 6-0, with Jay Rodriguez, Sadio Mane and Shane Long each scoring twice.

Dwight Gayle grabbed a hat trick, including two penalties, as Crystal Palace ousted Charlton 4-1.

At Norwich, second-half goals from Matt Jarvis and Kyle Lafferty and Sebastian Pocognoli's own goal sent the hosts through with a 3-0 victory over Premier League rival West Bromwich Albion.

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