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!n Amtrak passenger train lies on its side after derailing near Mendon, Mo., on June 27.Dax McDonald/The Associated Press

An Amtrak passenger train travelling from Los Angeles to Chicago struck a dump truck Monday in a remote area of Missouri, killing three people and injuring dozens more as rail cars tumbled off the tracks and landed on their sides, officials said.

Two of those killed were on the train and one was in the truck, Missouri State Highway Patrol spokesman Cpl. Justin Dunn said. It was not immediately clear exactly how many people were hurt, the patrol said, but hospitals reported receiving more than 40 patients from the crash and were expecting more.

Amtrak’s Southwest Chief was carrying about 207 passengers and crew members when the collision happened near Mendon at a rural intersection on a gravel road with no lights or electronic controls, according to the highway patrol. Officials were still trying to determine the exact number of people aboard. Seven cars derailed, the patrol said.

Passenger Jason Drinkard told KMBC-TV in Kansas City that the car he was in suddenly tipped over and people flew out of their seats and landed on each other.

“Seats were coming apart. Bags were going everywhere,” said Drinkard, who boarded at Kansas City’s Union Station. “And then, after it stopped, you could smell the fumes. And so people started panicking, thinking it was going to catch fire, so we tried to get out as quick as possible.”

It’s too early to speculate on why the truck was on the tracks, said National Transportation Safety Board Chairwoman Jennifer Homendy. A team of NTSB investigators will arrive Tuesday, she said. Trains won’t be able to run on the track for “a matter of days” while they gather evidence, she added.

At one point, KMBC helicopter video showed rail cars on their side as emergency responders used ladders to climb into one of them. Six medical helicopters parked nearby were waiting to transport patients.

Close to 20 local and state law enforcement agencies, ambulance services, fire department and medical helicopter services responded, Dunn said. The first emergency responders arrived within 20 minutes of receiving a 911 call, he said.

Passenger Dian Couture was in the dining car with her husband celebrating their 40th wedding anniversary when she heard a loud noise and the train wobbled and then crashed onto its side.

“The people on our left-hand side flew across and hit us, and then we were standing on the windows on the right-hand side of the car,” Couture told WDAF-TV. “Two gentlemen in the front came up, stacked a bunch of things and popped out the window and literally pulled us out by our hands.”

Passengers included 16 youths and eight adults from two Boy Scout troops who were travelling home to Appleton, Wisconsin, after a backcountry excursion at the Philmont Scout Ranch in New Mexico. No one in the group was seriously injured, said Scott Armstrong, director of national media relations for the Boy Scouts of America. The Scouts administered first aid to several injured passengers, including the driver of the dump truck, Armstrong said.

High school students from Pleasant Ridge High School in Easton, Kansas, who were headed to a Future Business Leaders of America conference in Chicago, were also aboard, Superintendent Tim Beying told The Kansas City Star.

Mike Spencer, who grows corn and soybeans on the land surrounding the intersection where the crash occurred, said everyone in Mendon understands that the intersection is dangerous, especially for those driving heavy, slow farm equipment. The approach to the tracks is on an inclining gravel road and it’s difficult to see trains coming in either direction, he said.

Spencer said he had contacted state transportation officials, Chariton County commissioners and BNSF Railway about the potential danger. Spencer, who is on the board of a local levy district, said the dump truck driver was hauling rock for a levy on a local creek, a project that had been ongoing for a couple days.

Amtrak is a federally supported company that operates more than 300 passenger trains daily in nearly every contiguous U.S. state and parts of Canada.

It was the second Amtrak collision in as many days. Three people in a car were killed Sunday afternoon when an Amtrak commuter train smashed into it in Northern California, authorities said.

The Southwest Chief takes about two days to travel from Los Angeles to Chicago, picking up passengers at stops in between. Mendon, with a population of about 160, is about 84 miles (135 kilometres) northeast of Kansas City.

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