The morning commute could be a lengthy one for thousands of commuters who take Highway 401 into Toronto.
An overnight multi-vehicle crash has shut down all express lanes in both directions along a 10-kilometre stretch of the busy route between Highway 404 and Allen Road.
Toronto paramedics say two people suffered serious injuries and a third person was taken to hospital as a precaution with non-life-threatening injuries.
The collector lanes remain open but drivers can expect it move slowly through the morning rush hour.