Skip to main content

Researchers have found that acetaminophen offers no help for back pain and only trivial benefit for patients with osteoarthritis in the hips or knees.

BRADLEY C BOWER/AP

The Question

My doctor says I should take acetaminophen for my osteoarthritis pain. It seems to help some, but not a lot. I have also recently noticed newspaper articles about the dangers of this over-the-counter pill. Should I be taking another pain killer?

The Answer

Story continues below advertisement

Doctors often recommend acetaminophen, also known by the brand name Tylenol, because they consider it to be generally safer than the alternative medications.

Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) – such as ibuprofen (Advil), naproxen (Aleve) and acetylsalicylic acid (Aspirin) – may cause stomach bleeding, raise blood pressure, affect blood clotting and can interfere with kidney function. As well, another group of pain medications – potent opioid-based drugs – can be addictive and also cause numerous side effects.

But just because acetaminophen is frequently recommended, that doesn't mean it's very effective.

"It is not a good analgesic [pain reliever], despite the fact that it has been around for decades," says Dr. David Juurlink, a drug safety expert and head of clinical pharmacology and toxicology at Sunnybrook Health Sciences Centre.

He points to a major review study, published earlier this year in the British Medical Journal. The team of researchers, led by Gustavo Machado of the George Institute for Global Health in Australia, analyzed the results from 13 trials in which acetaminophen was compared with a placebo (or dummy pill) in patients with either osteoarthritis (the most common type of arthritis) or lower back pain.

The researchers concluded that acetaminophen offers no help for back pain and only trivial benefit for patients with osteoarthritis in the hips or knees.

They also found that patients using acetaminophen were four times more likely than those taking a placebo to have abnormal results in liver-function tests.

Story continues below advertisement

Acetaminophen is thought to be fairly safe when taken as directed. That means patients shouldn't use more than the maximum recommended dose of 4,000 milligrams a day. Acetaminophen is normally broken down in the liver. If you take too much of it, the drug can cause serious injury to the organ.

What's more, it's fairly easy to unknowingly creep above the upper dose limit because acetaminophen is also found in scores of other products including allergy medications and cold remedies.

A patient who takes close to the maximum daily dose for pain could enter the danger zone by using a cold remedy that also contains a significant amount of acetaminophen.

In fact, Health Canada is currently reviewing its acetaminophen guidelines and could end up lowering the maximum dose. "Of the more than 250 cases of serious liver injury each year in Canada involving acetaminophen, over half involved accidental overdose," Health Canada said in a recent statement posted on its website.

Juurlink believes the medical community's faith in the effectiveness of acetaminophen isn't justified by the scientific evidence.

"It doesn't reduce pain scores a whole lot more than a placebo does. And a placebo has exactly zero side effects – that's not true with acetaminophen," he says. "I think if it were to be brought to market today, acetaminophen would not be approved" by government regulators.

Story continues below advertisement

The George Institute study may help explain why acetaminophen doesn't provide you with much pain relief. But does this mean you should switch to another drug? Not necessarily.

Juurlink says it's impossible to generalize. What's appropriate for one patient may not be right for another. "It depends on the type and the severity of the pain, and if the patient has other medical problems," he explains.

For instance, if the patient has ulcers or kidney problems, then a NSAID would be inherently riskier than acetaminophen. Furthermore, patients with a history of substance abuse should be prescribed opioids sparingly if at all.

So, you need to discuss your situation with your family doctor. But be forewarned: "The drugs we have for pain aren't all they are cracked up to be and very often they cause more harm than benefit," Juurlink says.

I don't want to paint a totally bleak picture for you. There is some evidence suggesting that non-drug treatments can actually help patients suffering from osteoarthritis. In particular, strengthening exercises and weight management can sometimes ease the burden on aching joints.

Some patients, though, are reluctant to exercise because it initially hurts when they move. In these cases, a pain medication may make it easier for them to begin an exercise program.

The combination of physical activity and medication may provide far more benefit than a pain reliever alone.

Paul Taylor is a patient navigation advisor at Sunnybrook Health Sciences Centre. He is a former health editor of The Globe and Mail. You can find him on Twitter @epaultaylor and online at Sunnybrook's Your Health Matters.

Report an error Editorial code of conduct
Comments

Welcome to The Globe and Mail’s comment community. This is a space where subscribers can engage with each other and Globe staff. Non-subscribers can read and sort comments but will not be able to engage with them in any way. Click here to subscribe.

If you would like to write a letter to the editor, please forward it to letters@globeandmail.com. Readers can also interact with The Globe on Facebook and Twitter .

Welcome to The Globe and Mail’s comment community. This is a space where subscribers can engage with each other and Globe staff. Non-subscribers can read and sort comments but will not be able to engage with them in any way. Click here to subscribe.

If you would like to write a letter to the editor, please forward it to letters@globeandmail.com. Readers can also interact with The Globe on Facebook and Twitter .

Welcome to The Globe and Mail’s comment community. This is a space where subscribers can engage with each other and Globe staff.

We aim to create a safe and valuable space for discussion and debate. That means:

  • All comments will be reviewed by one or more moderators before being posted to the site. This should only take a few moments.
  • Treat others as you wish to be treated
  • Criticize ideas, not people
  • Stay on topic
  • Avoid the use of toxic and offensive language
  • Flag bad behaviour

Comments that violate our community guidelines will be removed. Commenters who repeatedly violate community guidelines may be suspended, causing them to temporarily lose their ability to engage with comments.

Read our community guidelines here

Discussion loading ...

Due to technical reasons, we have temporarily removed commenting from our articles. We hope to have this fixed soon. Thank you for your patience. If you are looking to give feedback on our new site, please send it along to feedback@globeandmail.com. If you want to write a letter to the editor, please forward to letters@globeandmail.com.
Cannabis pro newsletter