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A man was killed in a shooting in midtown Toronto on Tuesday, the city's 33rd homicide victim this year.

Police are on the lookout for two suspects who reportedly fled the scene in a black car. The two men were believed to be wearing an orange construction vest and a green construction vest respectively, and are reportedly armed and dangerous.

The shooting took place early Tuesday afternoon in a service driveway behind a condominium complex, just southeast of the busy intersection of Yonge and Eglinton.

Police say they received a call about a person shot in an alleyway off Cowbell Lane around 2:50 p.m, with reports of multiple gunshots.

The victim was found in the driver's seat of a white Range Rover and pronounced dead at the scene by Toronto paramedics.

Police said they were canvassing the area for witnesses and for security camera footage in a brazen daylight crime that has shocked the popular but quiet midtown neighbourhood, the site of rapid residential and commercial development in the city.

But they could not confirm how many shots were fired, or whether the victim was targeted.

So far this year, shootings have killed 21 people in the city, three times the number killed in the same period of 2015 as occurrences of gun violence have steadily risen.

Toronto police have been calling for more cooperation in communities with gun-violence problems, amid fears that the city may surpass the 2005 high of 52 gun homicides this year.

Among other recent victims of the increased gun violence to hit Toronto, a pregnant mother of two was shot dead in a vehicle last month. Her infant son, who was delivered prematurely by an emergency C-section at 24 weeks, died on Sunday.

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