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Veteran U.S. tennis player Serena Williams waves to the crowd following her loss against Switzerland's Belinda Bencic during the National Bank Open in Toronto on Aug. 10, 2022.COLE BURSTON/Reuters

Serena Williams plays Monday night at the Western & Southern Open in what is expected to be one of her final matches.

It’s a big deal, even for a U.S. Open tune-up accustomed to hosting the world’s best players.

“Serena Williams is a global icon whose impact certainly transcends tennis,” tournament CEO Katie Haas said. “We are fortunate to have seen her lift our trophy on two occasions and to welcome her here for one of the last events of her incredible career.”

The 40-year-old Williams is preparing to walk away from tennis, saying she wants to have another child and pursue business interests. The 23-time Grand Slam champion has not said what her last event will be, but did make it sound as if her final farewell will come at the U.S. Open, which begins Aug. 29 in New York.

Next up for Williams is Monday night’s first-round match against 19-year-old Emma Raducanu, the defending U.S. Open champion.

If Williams advances, she could face 2016 Cincinnati champion Karolina Pliskova in the second round. There also is a potential quarter-final matchup with sister, Venus.

Serena Williams lost 6-2, 6-4 to Belinda Bencic on Wednesday night in Toronto in her first match since she elaborated on her future plans.

“She’s been a huge impact on the sport,” said Cincinnati native Caty McNally, who is making her fourth appearance in her hometown tournament. “As a kid I always watched her on the TV. I was lucky to have the opportunity to play her in the U.S. Open a couple of years ago. I think it’s important that she’s moving on and going to spend time with her family and explore other things in life.”

Novak Djokovic pulled out of the hard-court tournament on Friday because he has not gotten any COVID-19 vaccine shots and so is not allowed to travel to the United States. But the Cincinnati stop still includes several of the world’s top players.

A large crowd watched Raducanu and Wimbledon champion Elena Rybakina practice together on Saturday afternoon. Rybakina faces Egyptian Mayar Sherif in the first round.