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Toronto Blue Jays first baseman Edwin Encarnacion (10) receives congratulations from catcher Russell Martin (55) after he hits a home run in the fifth inning against the Cleveland Indians at Progressive Field in Cleveland, Ohio on Saturday, Aug. 20, 2016.Rick Osentoski

Edwin Encarnacion homered, Roberto Osuna bounced back from a nightmarish outing to record the save and the Toronto Blue Jays beat the Cleveland Indians 6-5 on Saturday night.

The Blue Jays were stunned Friday night on Tyler Naquin's game-ending inside-the-park home run off Osuna that gave the Indians a 3-2 win.

The latest matchup between division leaders also had plenty of drama, with Osuna retiring Naquin on a ground-out to end it.

Toronto built a 5-0 lead, but then Cleveland scored five times in the fourth.

Encarnacion's leadoff homer in the fifth, his 35th of the season, put Toronto back on top.

Joe Biagini (4-2) pitched two scoreless innings. Osuna also gave up a tying homer to Jose Ramirez on Friday, but pitched a perfect ninth Saturday for his 28th save.

Josh Tomlin (11-7), activated from the family medical emergency list before the game, allowed six runs in 4 1/3 innings. He gave up three home runs and has allowed an AL-leading 32.

Melvin Upton Jr.'s two-run homer, Russell Martin's solo home run and a two-run single by Devon Travis built the early lead.

Aaron Sanchez didn't allow a hit through three innings, but Cleveland sent nine men to the plate in the fourth. Mike Napoli's sacrifice fly and an RBI single by Ramirez made it 5-2. Lonnie Chisenhall's three-run homer ended a 10-pitch at-bat and tied the game.

Tomlin, who returned to his home in Texas on Wednesday, gave up Travis' infield hit that scored two in the second. Toronto scored three in the third on Martin's solo home run and Upton's two-run homer.

Tomlin won his first seven decisions and was 9-1 on June 26, but the right-hander is 0-4 with a 10.02 ERA in last four starts.

Sanchez allowed five runs – four earned – in four innings.

Blue Jays third baseman Josh Donaldson (jammed thumb) missed his second straight game. Troy Tulowitzki returned as the designated hitter after not playing Friday because of a strained calf.

TRAINER'S ROOM

Blue Jays: Manager John Gibbons thinks Donaldson, who hasn't played since Wednesday, will be available for the series finale Sunday.

UP NEXT

Blue Jays: RHP Marcus Stroman allowed two runs and struck out eight over 6 1/3 innings in his last start against Houston.

Indians: RHP Corey Kluber got the loss against the Blue Jays on July 3 at Rogers Centre, allowing five runs in 3 1/3 innings.

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