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The Buffalo Bills can change quarterbacks all they want following their second-most lopsided loss in franchise history.

Running back LeSean McCoy knows the abrupt switch from inexperienced and interception-prone Nathan Peterman to raw rookie Josh Allen won’t make much of a difference if everyone else on offence fails to perform Sunday in Buffalo’s home opener against the Los Angeles Chargers.

“Maybe Nate didn’t play well with the turnovers, but we helped out with that,” McCoy said, referring to a season-opening 47-3 loss at Baltimore in which Peterman threw two interceptions and was yanked after Buffalo managed one first down on 10 possessions.

“We gave up pressures, we had penalties, second-and-longs, third-and-longs. We didn’t make plays for him,” added McCoy, who finished with 22 yards rushing on seven carries. “It’s a team thing. Collectively, we didn’t play well.”

The meltdown, which included numerous blunders on defence and special teams, left coach Sean McDermott with little choice but to reverse course at quarterback.

A week after McDermott was comfortable with Allen developing on the sideline, the coach sped up the first-round pick’s timetable by making him the starter in saying: “It’s the right move for our team.”

At the very least, the switch spared Peterman from revisiting the dreadful memories of the last time he faced the Chargers in his first career start 10 months ago. McDermott’s decision backfired then, too, when Peterman was pulled after throwing five first-half interceptions of a 54-24 loss.

It’s now on the strong-armed and mobile, 22-year-old Allen to mask the numerous deficiencies of an offence featuring a patchwork line that surrendered six sacks, and a mostly unproven cast of receivers.

Quarterback certainly isn’t an issue for the Chargers after Philip Rivers topped 400 yards passing for the 10th time of his career in a season-opening 38-28 loss against Kansas City. What hurt were several dropped passes and the Chargers’ inability to stop Tyreek Hill, who had 169 yards receiving and two touchdowns, and also scored on a 91-yard punt return.

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