Cameroon forward Samuel Eto'o scored to help ambitious Russian club Anzhi Makhachkala beat Udinese 2-0 and reach the Europa League knockout stages on Thursday, eliminating the Italians in the process.
Last season's runners-up Athletic Bilbao, whose game in Israel against fellow Group I side Hapoel Kiryat Shmona was postponed for security reasons, were knocked out without playing while Lazio, Sparta Prague and Genk went through.
Christopher Samba and Eto'o scored in a three-minute spell in the second half to steer Guus Hiddink's Anzhi team into the last 32.
Samba headed in from a corner and former Barcelona and Inter Milan forward Eto'o raced clear of the Udinese defence before slotting the ball past Zeljko Brkic, ending an unhappy European campaign for the Serie A side who missed out on the Champions League after losing on penalties to Braga.
The Group A match was played in Moscow after UEFA refused to let Anzhi stage matches in the violence-plagued Dagestan region for security reasons.
A goalless draw at home to Tottenham Hotspur was enough to send Lazio through from Group J in a game where former England midfielder Paul Gascoigne, who played for both clubs, was a guest of honour.
Lazio president Claudio Lotito paraded Gascoigne around the pitch and fans held a huge banner with his photograph.
Violence against Spurs fans in Rome in the runup to the game had dominated headlines.
Panathinaikos striker Vitolo, who missed a penalty then converted another within 13 minutes of the first attempt, gave the Greek side a 1-0 win over Maribor to keep them in contention in the same group.
Sparta Prague's 1-1 draw at home to Olympique Lyon in Group I sent them through alongside the already-qualified Ligue 1 outfit, but the result meant elimination for Marcelo Bielsa's Athletic.
Steve McLaren's Twente Enschede were also knocked out after being held to a scoreless draw by Hanover 96. Elyaniv Barda's first-half header gave Genk a 1-0 win at Videoton as the Belgians progressed from Group G into the round of 32.