Gianluca Zambrotta, ambassador for the Champions League final, shows the name of FC Barcelona during the draw of the quarter-final matchesin Nyon, Switzerland on March 18, 2016.Christian Brun
Defending champion Barcelona will play Atletico Madrid in an all-Spanish quarter-final in the Champions League.
Barca aims to be the first team to retain the title since the format was created 24 years ago, and Atletico Madrid would be the third successive different winner from Spain.
Real Madrid, which won its 10th European title in 2014, was drawn against VfL Wolfsburg, which has never before played in the quarter-finals.
Bayern Munich will face Benfica, and Paris Saint-Germain will play Manchester City.
The first legs of the quarter-finals will be on April 5 and April 6, with the second legs a week later on April 12 and 13.
Atletico Madrid ousted Barcelona in the 2014 quarter-finals, when it made a surprise run to the final.
Real Madrid trails its two big national rivals in the league this season, but got a favourable draw on Friday.
"Real is, of course, favourite in both legs, but I think we will have two interesting matches," Wolfsburg director Klaus Allofs said.
Bayern, a five-time winner, will face Benfica, which won the last of its two titles more than 50 years ago.
"We can be happy with the draw, but we should not make the mistake of underestimating a team that's in the quarter-final," Bayern chairman Karl-Heinz Rummenigge said.
PSG was paired with Man City in a contest of two big-spending clubs striving to join the European elite. Neither has reached a European Cup or Champions League final.
The final is scheduled for May 28 in Milan.