Pity the Vikings. They get routed at home by Seattle, lose three defensive starters, then have a short week and a trip west to Arizona.
And the Cardinals have been even better than the Seahawks this season.
It's a difficult chore National Football Conference North co-leader Minnesota faces, particularly if nose tackle Linval Joseph (foot), linebacker Anthony Barr (groin/hand) and safety Harrison Smith (hamstring/knee) are not available. Those are some of the best players at each level on the defence.
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One solution against the high-powered Cardinals (No. 2 in AP Pro32) would be feeding the ball to Adrian Peterson as much as possible. The problem there: Arizona ranks fourth in rushing defence.
Peterson, who complained he wasn't used enough in the 38-7 loss to the Seahawks, is eager to get more carries against the Cardinals.
"That's the mindset of a player that wants to be great," Peterson says. "You want to be able to, when your number is called, to be able to make plays. Of course, I would be frustrated when you think about eight carries. But with the game getting away from us, that is what it is."
A seven-point favourite, the Cardinals also can clinch the NFC West with a victory over Minnesota (No. 10 in AP Pro32) and a Seattle loss.
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CARDINALS, 23-14
Knockout league tip
Pro Picks got knocked flat again, this time by the Bears. Anyone who has lasted this long in a survival pool this season is a genius. We're not, but will go for Kansas City this week.
No. 17 Washington (plus 3) at No. 20 (tie) Chicago
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Bears would be best team in NFC East right now. So …
Best bet: BEARS, 23-16
No. 12 Buffalo (plus 1) at No. 16 Philadelphia
Even after that win in Foxborough, Mass., we don't have faith in Eagles.
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Upset special: BILLS, 19-17
No. 8 Pittsburgh (plus 3) at No. 4 Cincinnati
The Bengals' shot at top seed in American Football Conference takes a hit.
STEELERS, 33-30
No. 18 Oakland (plus 7) at No. 3 Denver
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The Broncos' shot at top seed in AFC remains viable.
BRONCOS, 24-13
No. 20 (tie) Atlanta (plus 7) at No. 1 Carolina
Panthers have little worry about getting top seed in NFC.
PANTHERS, 30-16
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No. 22 Dallas (plus 9) at No. 9 Green Bay
Maybe this one will finish off "Cowboys are contenders" talk.
PACKERS, 26-24
No. 6 Seattle (minus 5) at No. 29 Baltimore
Seahawks are looking like contender for third straight Super Bowl trip.
SEAHAWKS, 26-13
No. 31 San Diego (plus 10) at No. 7 Kansas City
No team is playing better in AFC than Chiefs, who go for seventh straight win.
CHIEFS, 22-13
No. 28 Tennessee (plus 7) at No. 11 New York Jets
Jets don't do anything easily.
JETS, 21-19
No. 19 New York Giants (minus 1) at No. 24 Miami, Monday night
Giants don't do anything easily, either. Must be a Meadowlands thing.
GIANTS, 17-13
No. 5 New England (minus 3) at No. 15 Houston
Position meetings must have been fun this week for the Patriots.
PATRIOTS, 24-17
No. 26 New Orleans (plus 4) at No. 14 Tampa Bay
Have to love what Lovie has done with Bucs. Not so much what's going on in Big Easy.
BUCCANEERS, 33-31
No. 23 Detroit (pick-em) at No. 28 St. Louis
Who really cares, Part 1?
LIONS, 21-18
No. 25 San Francisco (plus 3) at No. 32 Cleveland
Who really cares, Part 2?
49ERS, 23-15
No. 13 Indianapolis (OFF) at No. 30 Jacksonville
Must win for Colts in AFC South race.
COLTS, 22-20
2015 record: Against spread: Week 6-10, Season (93-87-5). Straight up: Week 10-6, Season (118-74)
Best bet: 6-6-1 against spread, 8-5 straight up.
Upset special: 7-6 against spread, 4-9 straight up.